Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable
نویسندگان
چکیده
منابع مشابه
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides. However, the specific impact of N-methylation on passive membrane diffusion in cyclic peptides has not been investigated systematically. Here we report a method for the selective, on-resin N-methylation of cyclic peptides ...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2014
ISSN: 0044-8249
DOI: 10.1002/ange.201405364